gambogic acid造句

• In 2007, a research project focused on the mechanisms involved with gambogic acid's antitumor activity.
• Results supported the hypothesis that gambogic acid works to suppress nuclear factor-?? ( NF-?? ) activation that is induced by various inflammatory agents and carcinogens.
• Gambogic acid has also been found to bind to transferrin receptor1 ( TfR ) and rapidly induce cell apoptosis without competing with the transferrin ( Tf ) binding site.
• Gambogic amide, a derivative of gambogic acid, selectively activates TrkA ( but not TrkB and TrkC ) both " in-vitro " and " in-vivo " by interacting with the cytoplasmic juxtamembrane domain of TrkA.
• Cytotoxic xanthones ( gambogin, morellin dimethyl acetal, isomoreollin B, moreollic acid, gambogenic acid, gambogenin, isogambogenin, desoxygambogenin, gambogenin dimethyl acetal, gambogellic acid, gambogic acid, isomorellin, morellic acid, desoxymorellin and hanburin ) can be isolated from the dry latex of " Garcinia hanburyi " ( gamboge tree ).
• Small molecules such as amitriptyline and gambogic acid derivatives have been claimed to activate TrkA . Amitriptyline activates TrkA and facilitate the heterodimerisation of TrkA and TrkB in the absence of NGF . Binding of amitriptyline to TrkA occurs to the Leucine Rich Region ( LRR ) of the extracellular domain of the receptor, which is distinct from the NGF binding site.